Geometry is key to T-cell triggering

Geometry is key to T-cell triggering 05/03/2018 12:07 PM EDT A new study reveals the geometric underpinnings of T-cell triggering through the precise engineering of T-cell receptor geometry in all three dimensions. The researchers used nanofabrication to create a biomimetic surface that simulates the key features of the APC, presenting T-cell receptor ligands in different geometric arrangements, with different inter-ligand spacings arranged in clusters of varying size.  Full story at http://engineering.columbia.edu/news/geometry-t-cell-triggering Source Columbia University School of Engineering and Applied Science This is an NSF News From the Field item. Follow NSF:  This email was sent using GovDelivery Communications Cloud on behalf of: National Science Foundation Update · 2415 Eisenhower Avenue, Alexandria, VA 22314 · 703-292-5111